Capmatinib may be taken with or without food, but dietary components, dosing habits, and concomitant medications can directly affect efficacy and safety. The following explains administration, dietary choices, and contraindications.
1. Administration and Timing with Meals
1. May Be Taken With or Without Food
The recommended dose is 400 mg twice daily.
It may be taken before or after meals; there is no need to avoid meal times.
Keep dosing times relatively consistent each day, about 12 hours apart.
2. Swallow Tablets Whole
Swallow whole with water; do not break, crush, or chew.
Drink a small amount of water to help swallowing and avoid dry swallowing, which can irritate the esophagus.
3. Missed Dose and Vomiting
If a dose is missed or vomited after taking, do not make up the dose.
Take the next dose at its scheduled time; do not take a double dose at once.
4. Avoid Large High-Fat Meals
A high-fat diet can increase capmatinib exposure in the body.
Avoid consuming large amounts of fried or greasy foods around the time of dosing.
Keep the daily diet light and balanced; avoid overeating.
2. Dietary Choices and Nutritional Support
1. Ensure Adequate Hydration
Drink plenty of water during treatment to help eliminate metabolites.
If vomiting or diarrhea occurs, replenish water and electrolytes even more.
2. Choose Easily Digestible, High-Protein Foods
Such as lean meat, fish, eggs, and soy products, to help maintain strength.
Eat small, frequent meals to reduce the impact of nausea and decreased appetite.
3. Managing Decreased Appetite
Prioritize nutrient-dense foods such as milk, eggs, and fish.
Avoid greasy, spicy, or strongly aromatic foods.
Engage in appropriate activity before meals to improve appetite.
4. Monitor Electrolytes and Blood Glucose
Capmatinib may cause changes in laboratory parameters such as serum sodium, potassium, and glucose.
Include an appropriate amount of fresh fruits and vegetables in the diet; avoid extreme dieting.
If fatigue, muscle cramps, or palpitations occur, seek medical evaluation promptly.
5. Pay Attention to Liver and Pancreatic Function
Avoid long-term heavy alcohol use to reduce the burden on the liver.
If upper abdominal pain or worsening nausea and vomiting occurs, be alert to pancreatic problems.
Regularly recheck liver function, amylase, and lipase.
3. Dietary Contraindications and Drug Interactions
1. Avoid St. John's Wort
St. John's wort is a strong CYP3A inducer and can significantly reduce capmatinib exposure.
Do not use herbal teas or supplements containing St. John's wort during treatment.
2. Use Strong or Moderate CYP3A Inducers with Caution
Such as rifampin, carbamazepine, phenytoin, and efavirenz.
Avoid concomitant use with capmatinib whenever possible to avoid affecting antitumor activity.
3. Use Strong CYP3A Inhibitors with Caution
Such as itraconazole and clarithromycin, which may increase capmatinib exposure.
If concomitant use is necessary, monitor adverse reactions closely.
4. Grapefruit and Grapefruit Products
Grapefruit can inhibit CYP3A enzymes and may affect capmatinib metabolism.
Avoid eating grapefruit or drinking grapefruit juice during treatment.
5. Note Foods and Drinks Metabolized by CYP1A2
Capmatinib can increase caffeine exposure.
Drinking large amounts of coffee, strong tea, or energy drinks may worsen palpitations and insomnia.
Consume in moderation and observe your own response.
6. Avoid Excessive Intake of Photosensitizing Foods
Capmatinib carries a risk of photosensitivity reactions.
Use sun protection during treatment and avoid prolonged ultraviolet exposure.
Use sunscreen and wear long sleeves during outdoor activities.
7. Inform the Doctor of Concomitant Medications and Supplements
Including prescription drugs, over-the-counter drugs, vitamins, and herbal products.
Consult a doctor or pharmacist before adding any new dietary supplement.
8. Do Not Breastfeed During Lactation
Do not breastfeed during treatment and for 1 week after the last dose.
Dietary adjustments during lactation cannot replace the requirement to stop breastfeeding.
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