Infigratinib must be taken on an empty stomach, and food can significantly affect its absorption. Patients should understand the timing of dosing and meals, and avoid certain foods and gastric acid-reducing medications.

I. Timing Requirements for Dosing and Meals

1. Take on an Empty Stomach

Take at least 1 hour before or at least 2 hours after food.

Take once daily, at approximately the same time each day.

2. Swallow Whole

Capsules must be swallowed whole with water and must not be crushed, chewed, or dissolved.

If swallowing capsules is difficult, inform the doctor.

3. Missed Dose and Vomiting

If a dose is missed by less than 4 hours, it may be taken the same day.

If more than 4 hours have passed or vomiting occurs after dosing, the dose should not be made up; resume the regular schedule the next day.

Do not double the dose to make up for a missed dose.

II. Effects of Food on Drug Absorption

1. Avoid Taking with Food

Taking with food significantly increases drug exposure, especially with high-fat, high-calorie meals.

Low-fat, low-calorie meals also increase drug exposure.

Therefore, dosing on an empty stomach must be maintained to reduce fluctuations in exposure.

2. Avoid Grapefruit and Its Products

Grapefruit products should not be eaten or drunk during treatment.

Grapefruit can affect CYP3A4-mediated metabolism and may alter drug concentrations.

3. Maintain a Regular Diet

Dosing times and meal times should be scheduled consistently and not changed arbitrarily.

If decreased appetite occurs during treatment, ensure adequate calorie and protein intake.

III. Coordination of Gastric Acid-Reducing Medications with Diet

1. Avoid Proton Pump Inhibitors

Proton pump inhibitors should be avoided during treatment.

These drugs can reduce the absorption of infigratinib and may affect efficacy.

2. Interval for H2 Receptor Antagonists

If an H2 receptor antagonist cannot be avoided, take it 2 hours before or 10 hours after infigratinib.

Strict interval dosing can reduce interference with drug absorption.

3. Interval for Locally Acting Antacids

If a locally acting antacid is needed, take it 2 hours before or 2 hours after infigratinib.

It must also be staggered from infigratinib.

4. Attention to Dry Mouth and Taste Changes

Dry mouth and taste changes are common; drink appropriate amounts of water and choose light, easy-to-digest foods.

If oral discomfort affects eating, inform the doctor for management.