Qlosi Eye Drops is a cholinergic agonist ophthalmic solution developed by Orasis Pharmaceuticals, intended for the treatment of presbyopia. As an innovative ophthalmic medication, Qlosi improves near vision through a unique mechanism of action, providing a convenient treatment option for patients with presbyopia.
Indication of Qlosi Eye Drops
Primary Therapeutic Use
The primary indication of Qlosi Eye Drops is the treatment of presbyopia in adults.
Presbyopia is an age-related visual impairment characterized by the gradual loss of the eye's ability to focus on near objects, typically onset around the age of 40.
Through the action of its active ingredient, Pilocarpine Hydrochloride, Qlosi can temporarily improve near vision, providing functional visual improvement for presbyopic patients.
Specification and Characteristic of Qlosi Eye Drops
Dosage Form and Specification
Qlosi is a sterile, clear, colorless to slightly yellow, slightly viscous ophthalmic solution.
Active ingredient: Pilocarpine Hydrochloride 0.4% (equivalent to 4mg/mL).
Packaging form: Single-use vials, with a filling volume of 0.4mL per vial.
Chemical name: (3S-cis)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone monohydrochloride.
Molecular weight: 244.72g/mol.
Molecular formula: C₁₁H₁₆N₂O₂·HCl.
Composition
Active ingredient: Pilocarpine Hydrochloride (4mg per mL).
Excipients:
Hypromellose.
Sodium Chloride.
Sodium Hyaluronate.
Disodium Edetate Dihydrate.
Water for Injection.
May contain Sodium Hydroxide and/or Hydrochloric Acid for pH adjustment.
Storage Method of Qlosi Eye Drops
Storage Condition Requirements
Unopened products: Store refrigerated at 2°C to 8°C (36°F to 46°F).
Opened aluminum foil pouches: Once the aluminum foil pouch is opened, individual single-use vials can be stored at room temperature (not exceeding 25°C/77°F) but must be used within 30 days.
Protect from light: All products should be kept away from direct light exposure.
Single-use only: Once a vial is opened, it should be used immediately. Any remaining solution must be discarded and cannot be reused.
Precautions for Use
Administration method: Use a maximum of twice daily, 1 drop per eye each time, with an interval of 2-3 hours between the two administrations.
Contact lens use: Remove contact lenses before instilling the drops; wait at least 10 minutes after instillation before reinserting the contact lenses.
Concomitant medication: If other eye medications need to be used, an interval of at least 5 minutes should be maintained between their administration and that of Qlosi.
Contamination prevention: Avoid touching the eye or any surface with the vial tip to prevent contamination.
Special reminder for patients: Temporary blurred vision or decreased night vision may occur after using Qlosi. Patients should exercise caution when driving at night or engaging in hazardous activities in low-light environments. If flashes of light, floaters, or sudden vision loss occur, seek medical attention for examination immediately.
